Those who look back fondly on the old #5 Pebble obviously have a natural draw. For "fade is my life" me, there are no fond memories. They didn't call that the world's only dogleg par 3 for nothing.
Great submissions so far, Gene is right on re #13 Sand Hills. Terrifying is the right word for it.
Another great one is my personal whipping boy, #11 Shinnecock. 150 yards of terror itself there.... good call John Lovito.
There's actually a pretty good one at a horrid golf course out here called Tehama (Clint Eastwood's club). #3, only about 140 yards or so but uphill, partially blind, with a very nice green set against the hillside.
I'm sure there are lots of others... funny, I tend to like these types of holes in general... the more sky-line the green is, the better.
TH