In general, downhill holes are better than uphill I believe, with a ton of exceptions.
If a cart course (yes, I know most here have a visceral reaction against cart courses but there are many good ones), it helps a lot if the cart takes you up between holes, or even better if it is before #1 or between 9s, where a club employee can even shuttle walking players. One long uphill cart section does not disrupt playing flow and makes for better holes.