Tom -
At The Mines, there is a ridge/rise running across the fairway from left to right, at an angle: the carry over the left side of the ridge is shorter, the carry over the other side (the preferred line) gets progressively longer the further right you go. It's simple but effective: one time I went left and easily carried the ridge but didn't have much of a shot into the green; the next time I played I went right but didn't hit a good drive and failed to carry the ridge, so I had an uphill, semi-blind shot left.
At a local course, there's a deceptive tee shot that I don't like all that much (because I'm not good with visual confusion) but that I have to admit is effective and fair/playable: a kind of cape style hole except that you are (or seem to be) lining up at exactly a 90 degree angle to the fairway; the drive is over broken ground and marsh to a landing area that seems to stretch 'east to west' almost endlessly, but that seems to be only 10 yards wide 'north to south'. In truth, it doesn't stretch nearly that far (east to west) and is some 30+ yards wide (north to south). The tee shot gives our group fits every time, and terrible tee shots/flubs/topped shots often result -- but if you manage to put aside the visual confusion and just put a good easy swing on it with anything from a 4 iron to a driver, you find yourself always in the fairway.