There's one at a local club, The Fairways at Halfmoon, where the back-to-front green and moderate length give the best approximation of dart throwing you can have. That effect is enhanced with hazards protecting the front.
That said, because the elevation change will change the ball's angle at impact relative to shots played at the same elevation, I would think there are opportunities to provide novel options on these holes. Also, I think a lot would depend on how the land drops from tee to green. If the drop is over a gully, and the land is rising at the green, I would think creating an interesting dart throwing challenge is the starting point.
If on the other hand the land is stil falling away as you reach the green, you have an opportunity to provide a preferred option to play short of the green and use the land to move the ball forward, specifically if you can provide a green treatment that unduly punishes poor aerial shots. For example, if you could put concave features in the green and convex in the approaches, you could cheat some interesting alternatives on how to play a hole.
The key item being of course, being able to make use of ground falling away along the line of play for playing interest, if available.
Dave