Gary,
A generalization at best, but with some but not universal truth.
Before my first round of golf, I was really wondering how I would get back to the clubhouse after the 18th. I figured I might need bus money or something! When I saw the clubhouse sitting behind the last green, I thought the guy who laid this out must be a genius! A career was born.
So, I guess I would say the best routing is one that starts and finishes somewhere near the clubhouse, just for starters.