Brent,
Paul Cowley is the resident expert on this, with me trailing behind; I've spent several days on Jekyll every March for the past 15 or so years at a Georgia Athletic Coaches Association convention.
Pine Lakes on Jekyll has recently been redone, and is a lot of fun. Oleander is a good test, but stays a little wet, unfortunately. Indian Mounds by Joe Lee is the most scenic of the three, but the greens are spectacularly quirky. The old course, as someone said earlier, can't carry a vacation.
Hampton on St. Simon's is an easy trip, as is Laurel Island Links (by Paul's company) in Kingsland, and Osprey Cove a little farther down 95. The Brunswick CC is possible to get on and has at least some Ross credentials, and Coastal Pines in Brunswick is fun and affordable as well. If you head up to Savannah, Mike Young's Henderson GC is public and very good.
That's a partial listing. Be aware that there is very limited dining on Jekyll. As Paul says, St. Simons is much better for that, but it is a very easy drive over if you do stay on Jekyll.