I admit to being a fan of first holes that get you into the rhythm of the course, that prepare you for what comes on the following 17.
I don't generally like an overly difficult 1st, or a par 5, but that's probably just prejudice since I don't warm up and always play like crap on the first couple holes.
The mention of the first at Prestwick is wonderful as far as preparing for you for the rest of the course, if ever a first hole showed you what you'd face for 17 more holes, that's it. I really like Harbour Town's first as well, for similar reasons.
But I can't for the life of me understand the nominations for TOC's 1st, other than sentimental reasons. Don't get me wrong, I love TOC, but the first is the odd duck on that course, feels like it doesn't belong. The way the rest of that course plays, playing an iron off the first tee is just wrong on so many levels I can't even begin to name them. Then you have the Burn on the second, which while interesting, is also a shot you don't see anywhere else on the course. Swap it for Jubilee's first and then the pieces would all fit together much more nicely!