Jim,
The best opening drive in golf? You can't make a stronger statement than that. I've never played the course although I've been in the vicinity a few times at the Homestead. Do you have any photos or descriptions that might help to understand why you think so highly of the hole?
Some of my favorite opening tee shots include:
Merion (bunkering and historic setting, especially demanding with the lunch crowd 10' away)
Shinnecock Hills (offset fairway demand and overlook of course)
St. Andrews (so-so hole, but what a setting!)
Royal Aberdeen (the start to a fabulous nine, right by the clubhouse and thrilling undulations in front)
Sand Hills (Wow! is probably the response to an overwhelming majority of golfers seeing it for the first time)
Other fine opening shots include:
Pine Valley
Aronimink
Indian Creek
Muirfield
Manufacturers
Huntingdon Valley