Pat,
I don't think this is specific to my right-handedness, but when a course slightly obscures the target area (whether fairway or green) so that I can see some of what I want to do, but not all, I get uncomfortable.
Merion is my best case study for this. With very slight elevation changes and clever bunker construction I stand on the 4th, 6th, 7th, 8th, and 16th tees plus the 1st, 2nd (both fairway shots) 3rd, 6th, 7th 13th, 14th, 15th and 16th approach shots not quite comfortable with the target and its flow. For example, on #7 if I manage to hit it in the fairway I will typically have a wedge into the green and even if I no the exact yardage to the hole I have a difficult time visualizing the shot I'd like to hit. I tend to let the ground at my ball and on the green dictate what I should try and the green there sits just above eye level which eliminates the ability to see just where the little humps and hollows are in relation to the pin.
Firmness, once again, makes this situation absolutely sing...