I agree with Andrew. My home course is Huntercombe and for all the rounds that I have played there, I still have not worked out what is the best way to play the course - at least with my game.
Having said that, I find it a bit difficult to believe that a course, however well designed, carries an infinite permutation of challenges within it, to any one player. In theory that is true if you bring a totally different golf game to the course every day/week, but that is not true of most people. Sure, things evolve as you age, the course changes etc, but I am more inclined to say that while the strategic challenges after a certain point have become clear, the challenge of actually executing remains a perennial.
And the other factor that works against a player over time is that the more times you fail at a hole, the more it gets into your head, so you may have cracked the strategy of the course, but your own mental foibles prohibit you from doing what you need to do. And this factor, arguably, is likely to offset the improved knowledge you have of the strategic challenges.
Put into American, I suppose that translates that you more you play a course, the more likely you are to get in your own way.