The variations in certain regions do affect things. As Matt S mentions, in TX, it is from the south in summer, and most often, from then north in Winter. There is a course here in DFW featuring a shallow green fronted by a pond. In summer, no problem to hit and hold the green, but in the winter, with the opposite wind and harder green surface not many shots can even hold the green. In these cases, I always provided a "defensive" design, i.e., a deeper green, even though a tough pin would only be near the pond edge, similar to what I described earlier, i.e., larger, wider, and rounder greens in opposing crosswinds.
In the Midwest, it was always a bit easier, since it was SW in summer, and NW in fall, with a NE wind off Lake Michigan in Chicago only a 15% probability, but you could align the targets with the wind more reliably. Another rule of thumb on that was that the "Sunday Pin" should most often be located at the furthest point on the green in the wind direction, i.e., if it was from the left and behind, the SP would (as often as possible) be on the back right of the green and the aggressive player can use that wind to get close (i.e., add a club) or play a safer shot to the green middle. If the tough pin was on the front left, the wind would most likely carry them past the pin and they usually like at least a chance to get close to the Sunday Pin with some kind of shot, as they won't under club to get close and risk being in the bunker, which is tricky and okay, too, but not as architecturally tempting of a more aggressive shot.
Lastly, again in response to Charlie, many people have the thought that top golfers prefer all the signals to align to avoid confusion and instill confidence (i.e., the shot "fits the eye".) However, most people revere a course that calls for you to "hit all the shots" and the way to design that is in fact to use features to strongly favor one shot type over another, which is usually done by aligning all features as described.