Eric it just seems that you would aim to the high side knowing that the statistical advantage would be to play into the slope. Isn't that why you see so few greens that have a strong canter from front to back but many that have backs higher than front. I'm not saying that's great architecture, but most don't do it for fear of complaints from the golfing public.
Let's imagine a green is 30 yards wide. With the flag anywhere on the green, most people should still be aiming… at the middle of the green. If there's water right, many should be aiming at the left-center of the green. Regardless of the flag, and regardless of the slope (unless it's
really severe, in which case they're still playing to the "middle" as the final position, roughly).
If you want to play smart, tactical golf, the "high side" is almost never relevant. Just like the old BS about how you'd rather have a six-footer up the slope of the green than a three-footer 90° to the slope (or a downhill putt).
The Shot Zones of most amateurs are 30+ yards wide, so if the green is smaller than the Shot Zone, by trying to aim to the "high side" of the green… you're going to hit a lot more shots into the bunkers, rough, water… whatever.