Since the title of the thread is "Stongest Memories of Courses..." not memories of "Significant" courses, I'm going to take this in a slightly different direction. When I was a teenager in the 1960's, my brother and our friends used to take the bus (clubs and all) to play the Rock Creek Park Golf Course in Washington, D.C.
Strangely enough, over 50 years later, I still remember many of the holes. The one that stands out, though, was #13 (I think), a long, tight, uphill, par 4. As a 14 year-old with a pull cart, I remember huffing and puffing climbing that hill. The old-timers there called it "Cardiac Hill." I remember it vividly.
And, for the record, I pulled the Reverse Ira Fishman. I was born, raised, and spent the first 34 years of my life in D.C. and have lived in the Chicago area since 1985.