In Connecticut, the ~350-yard 10th hole at the course I learned the game on - Hop Meadow CC - rises 70 feet from the tee up to the green (the rise begins about 150 yards out from the back tee, so it's compressed into about 200 yards) AND twists pretty significantly to the left, with a green that itself probably falls 3 or 4 feet from back to front. I think Cornish did a wonderful job of pitching the fairway in such a way that it's about as steeply uphill as a fairway can be without the ball rolling backwards. The climb is close to being too onerous, but I don't think it crosses the line. Instead it's a short or mid iron from a more awkward stance than the player is accustomed to - I like it.
The property on which the course sits is basically two levels, and Geoffrey Cornish used three of the four par threes, plus hole 10, as the connectors. The par-3 third is about 155 yards and rises about 25 feet up a more mellow part of the shelf, while the par-3 9th and 16th drop about 75 and 85 feet, respectively.
Elsewhere in the area, the NLE Canton (CT) Golf Course had a par four where the approach shot was up about a 50-foot hill. Country Club of Waterbury's 10th rises 50 feet the last 140 yards. The green's a bit of a punchbowl, so if you come up short, you have no one but yourself to blame while you watch your ball roll about 40 yards back down the fairway.
#2 at Fairview Farm Golf Course in Harwinton, CT, rises 90 feet in about 390 yards.