The sad reality is, in the last two years I've probably played 200 rounds on 25 or so golf courses, and there are only a handful of holes where it made sense to do something other than aim for the middle of the fairway (after taking into account a draw or fade), to give myself the greatest chance of hitting the fairway for the approach. On holes with severe penalty on one side of the hole, It's almost always shade to the other side of the fairway, regardless of approach.
There are a few severe doglegs where bunkers or trees come into play to cut the corner (meaning you have to fly a certain distance), but if the ball is hit well, I'm still essentially aiming for the middle of the fairway, just past the dogleg.
The one course I've played where there are multiple plays that really encourage me to challenge one side of the fairway based on difficulty of approach (instead of safety off the tee) is Black Sheep, which has abundance width. I think the 10th on Pine Needles was a hole that I challenged a bunker I wasn't sure to fly for a shot at getting home in 2 as well.
That said, I can't think of one hole at #2 where getting in the fairway as far down as possible wasn't a premium over angle to green. Mid Pines, which I love encouraged to play to sides of fairways mostly because of fairways slopes. Olympia Fields North I would say was middle of the fairway every hole except 14 and 15 which would be left center only due to trouble on drive. PGA West Stadium was similar.
It really is true, unless you can push the edge of on F&F, which is difficult to do in most climates and soils in the US, it's hard to dictate angles without extreme width for the single digit golfer and better, because in almost all cases it's better to come at a green with the most lofted club from the fairway regardless of angle of attack.