Rob,
I have been going for 20 + years, sometimes 3x per year so...all depends on where you are staying.
North: Dunes is a must play, followed by Tidewater. Glen Dornoch is exceptional. Rivers Edge is a very good Palmer course. Great views and fun to play. Barefoot gets a lot of attention. I think the Dye course is the best, followed by Fazio. If you took away the faux ruins, Love would be forgettable. Norman course is on the best piece of land and good for a Norman, but not great.
South: As others have mentioned, Caledonia and True Blue are must plays. Caledonia is reaaaaaally easy and you should shoot a good number. True Blue is tough and one of my favorite layouts on the Strand. Pace is almost always 5 hours so budget for it. TPC of MB is also very good. 2nd tier, but still great are Pawleys Plantation and Legends - Heritage. Also, Debordieu (Dye) and Wachesaw (Fazio) might be options although they are private. The Private Norman down south is a forgettable round.
Middle/Heart of Myrtle: Grande Dunes is reaaaaaaallly modern, not much character, but in good shape. I personally don't care for the layout. The Legends resort with 3 courses is usually mentioned, but none of the courses would crack my personal top 15 on the Strand. The best is Parkland, hugely influenced/built by Strantz. Moorland is a bit tricked up but memorable. Heathland, a bit bland.
I hope this helps you.