Jim--
My family vacations at Pawleys Plantation and I am fortunate (though some people of particularly high taste on this site would disagree) to have been able to spend a lot of time there and to have played many of the golf courses down there.
If you are going down there for a weekend, I would pick a small area and spend your time in that area, because driving up and down Rt. 17 Business and Bypass and the other roads down there can be a time drain. If you want to make a point of playing Caledonia and True Blue, then playing Pawleys Plantation (which is, happily, in FAR better shape than it was earlier in the year, due in part to its sale to the Myrtle Beach National Group) and Heritage would round out the trip well, IMO. Founders Club is okay, but I'd place it behind the four I already mentioned.
If you want to stay in the middle part of the Grand Strand, you have courses like Indian Wells (older-school; good warm-up course to play on the trip), Prestwick (interesting enough Pete/PB Dye collaborative effort), the three at Legends (one designed by our very own Tom Doak and the other two are pretty interesting), Wild Wing (designed by our very own Jeff Brauer), the Witch (amusing Dan Maples course) and World Tour (if you like 'replica' courses).
If you want to go a bit north, the four courses at Barefoot Resort are pretty well-respected, as are Tidewater and the Dunes Club. Grande Dunes gets a good bit of love, but I am not a fan.
If you're looking for anything more specific (restaurant recommendations, other-than-golf amusement), drop me an IM.
Have fun on your trip. Myrtle Beach is an interesting place with a bunch of very good golf courses.
--Tim