Matt,
If you give me a hole with a dogleg I'm just going to hit it over the corner, or if that line makes me nervous for some reason I'll take less club and just hit to the corner. Unless the teebox is in a chute of trees so I have to take the "proper" starting line what's to stop me from doing this, unless you happen to have some very tall trees conveniently located to guard the corner? Modern equipment makes this a quite reasonable strategy, and reduces the value of being able to work the ball with the driver as a result.
Sure, it is a bit more risky, if I mishit it I may not make the corner, and drop it in the rough or bunker, etc. But I'm probably just as likely to do that on a straightaway hole from simply missing the fairway. A drive to an angled fairway often feels a bit easier to me, as there is a bit more side to side leeway then with a straightaway shot. So long as I know the carry distance and runthrough distance (i.e., I know the numbers, or I've tried it a few times and feel like I've got a good idea) I'm more confident on this type of shot than I am with a straightaway shot to a narrow fairway because I feel as though I have a lot more margin for error.
If you want to make good players uncomfortable, don't just give them a dogleg, give them a dogleg with a turning point in a place where it doesn't work too well for a driver, or use a bit of a double dogleg which would require working the ball since the "hit it straight over the corner" strategy will have very little margin for error.