Interesting question to start this thread.
There are some courses I play with flatter greens, which also happen to be some of the longer courses I'll play. I usually drop a wedge (60*) and put in some sort of other long club to use into greens on long par 4s, and as a second shot on par 5s. It also gives me options off the tee on mid length par 4s if need be.
Shorter courses, or courses with lots of moevement in the greens, and I put the 60* wedge back in, and say a 19* hybrid, instead of a 18* 5 wood and 22* hybrid combination used on longer courses.
This means I always hit full shots with the wedges, and can attack pins, with the knoweldge that a short side miss recovery can be played with the lob wedge.
MM