I think I have had the same set up since 2000, other than switching a 1-iron for a 2-iron and a 58* wedge vs. a 60*. Otherwise it's Driver/3-wood, 2-PW Irons, 51* and 58* wedges, and a putter. Pretty standard I guess.
But back to the question, no I really don't ever change my clubs in and out, maybe my ball, but not the clubs.