The approach to the 600 yard par 5 4th at Merion East can result in a downhill lie equal in difficulty to the 15th at Augusta. There is a temptation to hit an extra club to reach the bottom of the hill. Typically the player faces a downhill lie with an approach that must carry a creek (Cobb's) and two bunkers (not among Mike Cirba's favorites) to a green that runs front to back much more so than it appears due to the grain (yes, Mark Fine, due to the grain).
The short 8th also has a downgrade the closer you come to the front bunker. It is often better to have a fuller shot into the green as approach shots, although with a wedge or lofted iron, constantly roll off the back. With a full shot, you can hit with more spin to stay on the green.
You don't want a downhill lie on 11 because that is a very demanding approach no matter how flat the lie. It shouldn't be too hard to find the level lie however given the downslope preceding the LZ as it widens out a bit at the flat area but the downslope in the fairway is rather narrow. This encourages a longer tee shot for position and stance.
One of the most difficult downhill lies to a very tricky green is found on the 18th hole. From the member tees, a good drive almost invariably ends up on a downslope at the base of another hill with a valley beyond and fronting the green. The green can be totally hidden and you must hit a precise lofted approach to hold that very difficult green. The front half slopes back to front and the rear half slopes front to back. Depending upon the pin position, it is a very difficult shot from a downhill lie. From the back and very back tees, the balls often end up on the downslope below the Hogan plaque. A very long iron or fairway wood approach is required from an awkward stance.