No course would truly make me want to quit...but this one is close: TPC Las Vegas.
It's the epitome of bad architecture. It's in the middle of a housing complex, it's too narrow for how windy it can get, every green is elevated and they keep the greens too firm and fairways too lush. It was honestly the worst course I've played by a long shot, and to top it off it was ludicrously overpriced! It's the exact type of course that gives golf a bad rap, no fun, too hard, too expensive, too long to play.