Off hand the closest I can come are 1,9 and 18,19 being uphill. 10 is steep downhill. Golf du Chateau de la Babette near Brussels.
It's a serious especially 16 must be up there for some serious vertical climb as well, though it's a long par 5 playing steeply uphill. One of the most tiring par 5's I've ever walked, especially given it's placement at the end of the round. 19 is a doozy but oh so worth it...
The way for this to happen would be to have course that doesn't return to the club house. after 9 I suppose or one that is located on the side of a hill with two mirror imagine routing patterns, one clockwise and the other counterclockwise. No doubt it exists.