Mac,
I think that the average golfer hardly knows Prestwick, so depending on how you look at it, it could be a bad thing. Obviously TOC is going to be famous because it is/ once was the oldest golf course on the planet, but without a major championship there, people are less likely to know about it.
Now, as Adam mentioned, there's no way the R&A doesn't host the it's most important championship on its home course. However, if Option B were considered because of its history, would the exclusion of TOC, "the grandaddy of them all," lead to a discussion about the evolution of technology?
I would like to think that if Option B were taken, there would start to be a serious debate about rolling back equipment so these great courses could still put up a good fight against the best.