A few that come to mind:
North Berwick 16...I DO play it differently because it's my home course. Most single digit handicap players don't think about laying up in front of the burn, but I always do if there's anything but a howling west wind (helping). The rationale is that, although the green is treacherous, most big scores on that hole start from the tee. OB hard on the right and the burn bring big numbers into play, whereas if you play short of the burn, in general, you'll not do worse than a 6, which isn't a round breaker. And very often one will make a 4 or 5 with a front pin.
Barnbougle 12 - I gave it a crack both times, but unless it was downwind, I think I would take my chances on playing a hybrid out left and bumping something into the green.
Brancaster 8 - I would likely lay up a lot more with my second if I was in a medal. But even if I'm on the edge, I normally go for it in a match because pulling it off feels incredible.
Pebble Beach 8 - I'd imagine that if I played all my golf there, I would play for a 4.5 and be happy with a 20 foot putt for par. Play a hybrid / 3-wood well left, then play well left of the green to take the cliff out of play, then hope to flop something on the green and play for the 2-putt.