Tom:
One of my favorite tee shots I've ever built, and one that more players seem to have trouble with than any other, is the third hole at High Pointe, a long par-4. The fairway is down in a valley that runs slightly from left to right, and the green is back up on a hill so you can see it clearly from the tee down the right edge of the treeline.
There are a couple of bunkers on the outside of the fairway on the left, which you don't want to aim at because you can go in them ... so most people just unconsciously aim at the flag and wind up in the right rough, because the fairway is offset from the beeline.
I have gone back on a couple of recent designs and tried to do more of this ... starting the fairway from the left or right, instead of having it run back toward the tee. On open ground, you can just put the tee off-line to the fairway, but when you have to clear vegetation to make the fairway it's much harder to remember to start it at an angle, and I think that's why you don't see it very often.