Let me tackle the premise, before I offer nominations.
Premise
Which course has a noteworthy hole, that might actually not be the best hole on a course littered with others that, upon reflection, are stone-cold, borderline legendary, golf holes? The only holes under consideration are holes on that course, not to be contrasted/compared with holes on other courses. Some pundits might chime in with That course's holes aren't as great as that other course's holes and this would be a plausible, if not relevant, point for consideration.
In addition, the number of posts to reach this pinnacle matters, as proposed by the author.
For me, the key is identifying courses that have the original version of a hole thought to be iconic and good, and then cull the ones that don't have 12-15 other holes that top the iconic one for best-hole-on-course stature.
Conundrum
As good as #16 is at Cypress Point, is it installed elsewhere? No.
As good as Redan North Berwick is, is it installed elsewhere? Yes, with different flavors, to boot. Some drop, some climb, some move leftward, some move rightward.
The second part, the number of posts, demands a healthy population to have played the courses. I've not played NB, nor PD, nor PV, so I would not advance off the touch line on those three. I have played some top-shelf courses, and I would volunteer that NGLA also has 17 great holes and one very good hole, with the very good hole being Eden. Did nothing for me, visually nor strategically.
Resolution
The time-honored tradition of Which mood holds me hostage delivers the answer. What makes a hole great and who makes a great hole are two questions that I ask myself. Elements of golf course architecture, topography, and nature, conspire to create an unforgettable, unmatchable golf hole. The 13th at Merion East becomes greater for one who ages, as its wee length never takes 1, 2, or 3 out of play.
Nominations
I'm going to put Sleepy Hollow (NY) as my first private USA nomination. I'm going to put Eastward Ho! as my second private USA nomination.
I'm going to put Pasatiempo as my first public USA nomination. I'm going to put Tobacco Road as my second public USA nomination.