Jonathan,
My feeling is that finding that smallish, sloped green or a nearby safety outlet that would leave you in a reasonable position to make birdie or par would be much more luck than skill. The more firm and fast the conditions or variable the wind is, then lower the probability.
Others who've played it more than I could comment on pin placement influence on the tee shot, but based on my experience, you've got be very precise with your approach if the pin is on the front part of that green--if you can precisely place your drive right in front of the green, OK, but how many can reliably execute a 280-yd shot to what I recall is a very small patch of safe terrain?
I think it's far less risky to put something in play off the tee, from 5-wood to 4-iron, and then deal with the tricky approach.
In match play, if you were downwind, down 1 or 2 in your match, and had been hitting the driver well all day, maybe take a driver and go all out for a win--otherwise safety first. If you're going for a score, I don't think driver makes sense at all...