Another "bad" combo (though a variation of the above) is a mandatory layup with a shorter club than the shot you are then left with into a par 5.
Uphill, uphill combo, with the second shot blind.
Emphatically agree with the first. I pretty much HATE any mid-to-short-iron layups, even if the third is a wedge.
Disagree with the second -- unless you mean REALLY blind, so you can't even see the flag; or unless you mean a second to a green that won't hold the shot hit with the required club.
I like uphill, semi-blind approaches (like Mr. Brauer's tribute to the Dell green -- have I got that right, Jeff? -- at Giants Ridge Quarry).
Generally: I like demanding/demanding, or demanding/demanding/demanding -- which is not to say penally demanding/penally demanding or penally demanding/penally demanding/penally demanding.
I like to have to Do the Right Thing with this shot in order to have a good chance of Doing the Right Thing with the next shot, and so on.
In other words, generally: I don't care much for Bomb Away With Impunity drives, and I don't like Who Cares Where You Put It layups.
Beyond that, shots that go together well and memorably are any combinations that I haven't played a thousand times before.
But I particularly like (in fact, LOVE) holes that allow me to Do the Wrong Thing with one shot and still leave the POSSIBILITY (if not a "good chance") to Do the Very Right Thing with my next. If I hit it into the trees, I love the CHANCE to hit it around or under the trees and run it up to the green. If I hit it into the rough, I love the CHANCE to find that little opening between the bunkers and run it up onto the green.
Give me the CHANCE for a "heroic" recovery, and I'll be a happy boy -- even after I mess up my recovery shot.