Michael,
I like your concept of staggered or more/less difficulty on either side. While aiming for the middle is still a strategy, as is picking an aiming point and shot pattern to get it there, I have to think there would be some temptation for most players to overthink it when there is an imbalance of penalties. Of course, the most disciplined players will stay in the safest line/zone for their dispersion pattern.
I remember Scott Fawcette telling me that Rees Jones holes really offered the best strategy for pros, and I am sure that would apply to RTJ Senior as well, and maybe Dick Wilson. So, holes bracketed with FW bunkers and greens surrounded by bunkers are by that measure, as strategic as any, while most of us would call them penal. There must be some limit on just how close to the middle we can aim, but strategic nonetheless.
I have been debating this in my mind over the last year or so. I have mostly changed my mind that if low score is your objective, the new strategy should probably always be employed. My questions are, did the strategy develop because of the architecture players have seen the last 40 years? Is it so bad if the strategy of any shot is to make that one successful, even if not the next one, as is presumed (but never statistically proven) that angles do matter?
It would seem that angles then might be reserved for a select few holes, perhaps favoring the last 4, where the end of the match might be the thing that makes taking a risk more likely, as in "what do I have to lose?"
Lastly, the old strategy always presumed that playing the non-preferred angle was sort of fatal, but in reality, if you come from the "wrong" side, it changes the angle and strategy just as much as if you approach from the so-called "right side." Over time, you can again choose to be conservative and the putting vs hitting a hazard balance out. It isn't "I can go for the pin" vs. I can't. It is that I am 30% likely to do better from this side than that, and 70% less likely to do so.
It also occurs that when the 50% make rate is about 8 feet, that it really is foolish to fire at flags, because you are only rarely going to get that close, while taking chances might raise your bogey rate by 50% or more. That is balanced out by your competition - if they are all doing it, you almost have to, and many pros have told me that. With so much money available, there may not be that big a risk to aiming at flags, as at worst, you will still make a nice living, even if you don't win that tournament.
For an important once a year tournament for high level ams, playing for pride, playing the odds probably still makes more sense.