The first 6 holes at Waterwood National (Roy & Pete Dye, '74) near Huntsville, TX go 442, 225, 413 uphill, 450, 425, and 443 to small well-protected greens with no real option of running up an approach shot, except perhaps on the par-3 2nd. Every shot in the stretch is demanding, and big numbers are possible on each hole. Holes 3-5 are excellent holes.
Probably the toughest opening stretch I've played, not taking into consideration course setup, weather, etc.
Too bad most in this DG will never see it because it's so far off the beaten path.
Honorable mention:
Pete Dye GC
Prairie Dunes
Austin CC