Haven't played Interlachen yet, but Orange Tree many times. As a straight hitter, I've used Orange Tree to qualify for some FSGA events, but it's tight and big numbers are all around.
One thing to keep an eye on is the bunkers near the boundaries. I've seen many shots land on the edge of a trap which looks to be fine, but take a large bounce out of play. There are a few holes with water on one side and OB on the other. They seem to look like you should play away from the water, but the penalty is so much more if it goes OB. Much of the time the OB is nearly as close to the fairway as the water. Also because the boundary is pretty tree lined, the grass cover near the edges isn't always the best and balls can roll or bounce a little more than expected.
1, 2 and 10 are all reachable par 5s, but be careful. Missing the green on 1 or 10 can easily end up with a penalty, and depending on where the pin is on 2 (especially back right), you can be close to the green with not too fun of a shot. 9, 12 and 18 are demanding par 4s, and require two good shots. There are a number of birdie holes as long as you keep it in play. All the par 5s are good chances if you don't try to push too hard. Depending on your length, you could have irons into a couple, but be aware of what's near the green. I think they were rebuilding it, but the front bunker on 10 seemed to be a good place to put your second. It always seemed that no one I played with would make birdie from there. You need to be patient and know where you can miss.