I agree that this is a great topic. Our opening tee shot presents a little of this in the form of a pitched DZ. The hole varies from 445, 390, 345 and 330 but the DZ for most is right where the fairway pitches pretty strongly form right to left. For the opening tee shot here is what you have:
1. A "s" shaped creek that crosses in front of the tee, goes left all along the DZ, crosses back in front of the green at a l-r angle and goes right along side the green.
2. The FW is wide but it is an intimidating first shot. The "bail out" is right exactly where you would be left with a hanging right to left lie. You would also most likely be in light rough though the right side of the fairway also pitches left.
3. The left side along near the creek is flat and opens up a perfect angle to the green, but the creek is very much in play.
4. Hanging a shot right also can leave you with an intervening overhanging tree branch. The tree is on the FW side of the creek and certainly comes into play fro shots from the right rough. Not in play from any portion of the FW.
5. The green has the creek to its right but the green is segmented roughly into four quarters. Front left is at grade to the bailout fairway on the left. Front right is low and is the easisest location. Back right is high and the toughest location by far to get a ball on that back right plateau. Back left is high but then falls away and left. Balls carrying to the back left section often trickle off the back of the green.
6. There is a bunker far left of the green. Most use it directionally off the tee but it was meant to trick you into flirting with the creek as much as anything. It also looked cool
and serves as the buffer/transition to the second tee. When teeing off on #2 it looks like you are standing on top of the bunker.
Again, the opening tee shot is easy to "bail out" on the high right DZ side and leave yourslef the hanging lie to a green that is not receptive to a hard, hooking right handed approach
And yes, I know, the cart path is hideous
My seniors would have killed me if I moved it farther up the hill to the right and I still have to make $$$
Some pics: