I'm glad this came up again. My thing with it is that there are basically six places you can hit it. Left trees, left fairway, center bunkers, right fairway, right rough or short of the center bunkers. Of those, the difficulty of the following shot from easiest to hardest is as follows:
left fairway
right fairway
right rough
short of the center bunkers
center bunkers
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left trees
Of the fairway options, the ease of hitting each is in order:
short of the center bunkers
right fairway
left fairway
I always used to play short of the center bunkers, but I'd play it a little safe and then not focus and I ended up hitting 5 iron to the green all the time and it's offset against you and awkward, so I have dropped that option. So the best option is left fairway, but it's harder to hit than the right fairway and the risk of the left trees is pretty high. Hit it in there and you're playing a long third shot, virtually guaranteed. The right edge of the fairway as an aiming line gives me the safest set of options. I should hit either the fairway or the right rough. That rough is pretty light, so doesn't really hinder an approach shot all that much. Plus I hit my wedges pretty high, so that shot from out there can hold the green and worst case I have a chip or maybe a bunker shot.
Of course, with Mark's shot shape, hitting that right fairway is fairly hard and so I can certainly see how the left option works better for him. Takes all sorts.