I made the drive from Minneapolis in June in 3 1/2 hours. You can bust it up Hwys. 35 & 53 but you need to slow down once you get on 2 lane roads like hwy. 169(55 mph). Also, DO NOT SPEED through Gilbert, just east of Hwys.53. The limit is 30 mph and they mean it!
If you take it casually, it might take you 4 the first time you go.
Of course, you could fly into Duluth or Hibbing. It's 70 miles from Duluth and about 30 from Hibbing to Giants Ridge.
Also, it would be a good idea to reserve a tee time. The place has been very popular and it may only get worse. Late September and early October is the peak for fall color and very busy.I'm playing again in late Sept.
The course may close in mid October. They don't take any chances with frost since the tees, fairways and greens are bent grass.
Texsport