You can argue Euro has a shot at sweeping the first three matches -- Bubba can be (and has been, somewhat, so far) streaky, and Donald had a great afternoon. Poulter is a stud, and Bradley might be favored against anyone save for Poulter or McIlroy, and he got one of those guys. So it's not inconceivable. And Molinari and Kaymer anchoring the line-up has them going up against the only point-less pair of US players (and Tiger continues his career-long stretch of somehow dodging every top Euro player while running up a solid RC record in singles).
To me, the really tough matches for Euro are those guys going up against the Johnson brothers, Dufner and Kuchar, all of whom have played really well. Oddly, a key match if Euro sweeps early could be Lawrie-Snedeker -- few people remember that Lawrie won his singles match in the white-hot craziness of Brookline in 1999, so he's faced this before. And Snedeker, in singles, hasn't.
I'd say odds 3-1 that US wins; Euro does have a shot. But I don't expect it.