Of the big/to biggish American cities I have seen only a few really have a sense of cohesion and beauty and that is if we focus only on the traditional centre of the city. Most are a sprawling mess and over-reliant on cars - which is the main reason for lack of cohesion. There are reasons most people point to Euro cities as magnificent.
Ciao
As is often the problem with American cities, a sense of cohesion and beauty.
Sean,
I understand you're point regarding an abundance of cars and sprawl here in the States, however, that's a direct by-product of a much larger population on average. While some of my favorite cities are in Europe, there are quite a few cities here in the States that are world class...IMO, New York City, Chicago, Boston, San Francisco, Minneapolis, and Charleston being my favorites. Of those you really would only need a car in Charleston, as the rest have extensive public transportation.
As to not go too far off topic, Minneapolis currently has a fantastic bus system, which is hugely popular with commuters, and is either the 1st or 2nd best bike city in the country, thanks to numerous bike-only "highways" which are a very popular way to commute into work here (me included). Plus, they are expanding on their light rail system. All of this in addition to numerous parks and natural space which does a great job of breaking up the "sprawling mess."