Tommy,
Many moons ago I used to play some at Los Serranos Country Club, South Course down in SoCal. It opens with two and has six total with a par of 74. I caddied for a freind once who was in a qualifier for the SoCal Amateur. He went birdie, birdie to start, but stumbled into the low 80s by the end of the round.
Cheers, Jeff
About 15 years ago they lengthened the second hole to make it a true par five. It used to be a short hole and fairly easy for a par five. I believe 16 was that was as well, but I don't think they changed that hole. I moved out of LA and haven't played there in years, but my understanding is that they got an infestation of a particular beetle that killed a lot of the Eucalyptus trees. They lost some 5,000 trees or so.
That's the only course I've played that opens with two par fives, but I have played another courses that closes with two par fives, and four of the last five holes are par fives. The Victoria Club in Riverside, CA finishes with 3, 5, 5, 3, 5, 5, so the 12th hole is the last par four you play. It's a very old course for the region, built in 1903. Pretty short and really tight, but a lot of fun to play. It was our home course my senior year in college.