Schenley Park Golf Course in Pittsburgh crosses a well traveled city road on 3 holes.
In fact there is a sign at each end of the road declaring that risk is assumed by the drivers, that neither the golfer nor the course is responsible for damage -- and the sign lists the city ordinance declaring it. There are also lots of cyclists and walkers on this road because the golf course separate the Squirrel Hill neighborhood from Carnegie Mellon (and lots of profs & students live in Squirrel Hill).
#2 is a dog leg right par 4. First shot is parallel to the road. Then you hit a wedge over the road to the green. There is actually a chain link fence that boarders the road about 8 feet high but with a 2 foot gap at the bottom. You have to hit your drive left of the fence so you have room to wedge over the fence. The fence prohibits skulled shots from killing drivers/walkers/cyclists. You can see the shadow of the fence parallel to the road (on the north) if you look closely.
The other two crossings are far less dangerous. Both holes (which are side-by-side) are 300 yard par 4s, I think they're 8 & 17. The tees and greens are elevated and the road is in the valley. Basically drives just bang into the side of the hill. If you're lucky the ball sticks and you have an uphill wedge/punch. If you're unlucky the ball rolls all the way back to the bottom of the hill and you have a long, very uphill 2nd shot. The trees look like they're in the way of the tee shot, but they're well below both the tees & the greens because the valley is deep.
Awful course. But cheap and right next to campus!
Funny this is my advisor in grad school lived just on the other side of the course from campus. So mornings I'd play I would be on the lookout for him walking to school and try to hide if I saw him coming.