Ben--
Interesting that you say that, because I think that ANGC would be less of a problem than most courses off the tee for the simple fact that there is no long rough. It's all short, tight fairway and "first cut," which is probably a little shorter than the semi-rough at most courses. I think that if a mid-handicap player does not wail away at every drive, he should be able to get the ball near the green without too much problem (relatively speaking, of course) on many holes.
Like many have said, it would be all about the game from 100 yards and in. I think a good caddy would save a 10 handicapper a whole lot of strokes around and on those greens. I really think there would be a sporting chance of breaking 100 if you gave me a 10 handicapper who went out, knew it was going to be a bloodbath, and played for bogey on every hole. I'd give such a player a 15-20% chance of breaking 100.
I am a scratch player and I have always thought that of all courses where the American major championships are held, ANGC would yield my best chance of breaking 80, largely because of the lack of long rough. Of the players in the field this year, I'd say I would be in the 20th percentile in terms of driving distance (that is to say, 80% of the field would be hitting it further than me on average). If I had a decent day hitting my irons (which I consider the strongest part of my game historically), I might be able to give myself at least a few looks at birdie, especially on the par 5s. If I did that and kept my wits about me the rest of the way, I think I might be able to shoot 78 or so.
If you took me to Bethpage or Oakmont or Medinah and had me play those courses at US Open/PGA Championship setup, I wouldn't break 85. Any shot into that kind of rough would spell at least bogey 90% of the time. But at Augusta, I'd be in short rough or pine straw (two surfaces with which I'm quite familiar, if not 100% comfortable). I love fast greens, so I think I would be excited to step up to every putt at ANGC, which might help.
NB: I played a practice round with Byeong-Hun ("Ben") An, who shot 78-77 this year, a few years ago before an AJGA tournament. If Manassero made the cut there, I think that An probably could have as well. I don't think it would be out of the realm of possibility for me to shoot 78 if I played well. So, if my scratch would be more like +6 or +7 at ANGC, I would estimate that a 10 hcp would have to add twice that, so another +12 to +14, for +22 or +24, making "par" effectively 94 or 96. I think it would be possible to break 100, but a good caddy would be crucial.
--Tim