Well here I go again. Playing zero rounds on Bandon Dunes is just flat out nuts, in my opinion. But to each his own. However, as far as giving advice to a first time visitor, you absolutely HAVE to play it. It's a fantastic golf course. I tend to find myself defending BD all the time on threads here, just because I often feel like a voice in the wilderness on GCA, where the generally held position is that it is far inferior to the other two (soon to be three). I just don't see it.
I'll second all of Bill McBride's picks. I mean you simply HAVE to see and play 16 on Bandon Dunes. It's a one-of-a-kind hole and absolutely spectacular. And in the summer wind it's one of the more thrilling tee shots at the resort to try and decide just how aggressive you want to be.
Anyway, in addition to the aforementioned 4, 5, 15, and 16, I would call 1, 2, 6, 10, 11, and 12 all terrific holes. Bandon Dunes will absolutely beat the pants off of most of the golf courses that most people play their entire lives. The amazing thing is that the other two (soon to be three) courses at the resort are better, and in some cases (PD for sure) WAY better. That's why the place is so damned great.
OK, that's my defense of Bandon Dunes for today. Don't wanna be a broken record.