I believe that a routing that is more dominant with/against the wind is easier to play than one that is totally crosswind. Of course, triangles are great when they fit. That doesn't really happen on many sites, especially when trying to fit housing in.
I can recall one of my designs where the topo suggested an east west course (for the most part) but the wind was north south, resulting in some interesting design decisions, some of which my client made for me......
Feature design is affected - things like greens and fw getting wider on crosswind holes, deeper on downwind holes, etc., frontal openings on downwind holes. Also, I have learned that turf type affects design on really windy sites. For example, bent greens in Texas facing south need to be flatter, or the humps dry out. If facing north, they can stand the winter winds. However, when some of my courses converted to Bermuda greens later, the north facing greens burned out every winter where there was a high spot.