The lack of a place to go to the bathroom at the point on the course furthest from the clubhouse. That's very uncomfortable.
Patrick, my home course has several "misaligned" tee boxes. On 2, a short par 4, the tee box is parallel to the road OB left. As such, it points about 10-20 degrees left of the fairway - into the rough and the one big tree left. Most usually see this and overcompensate, hitting their drives into the single row of trees right. This isn't a bad place, actually, as long as you can hit an 80-100 yard low running punch shot between the unimposing bunkers 20 yards short of the green. On many occasions, the golfer overcompensates the next time around, trying to draw the ball and hooking it left into the rough, the tree, or even over the road.
On the 3rd, a 90 yard par 3, the narrow tee box runs along that same road, to a two-green complex. Rarely is the shot square to the tee box. The greens are small, and long is no good, placing a premium on accuracy for what should be an easy shot. This hole yields fewer birdies than you'd think.
The 4th, a short par 4 with a sharp dogleg left, the tee box points down the right side of the first 100 yards of fairway. Most end up hitting their drives well through this short area into the sparse trees right, and the bombers go down a hill into a tall grass hazard. Tee hee! The well thought out strategy is to aim 30-40 degrees left of the tee box alignment, and anyone hitting the ball more than 200 yards needs to draw it as well. Not that I'd recommend going more than 200 on this hole, which brings a shallowish valley with thick rough into play.
All three are short holes, so I defend the teebox misalignments.
Cassandra