Consider tying in two regions, for example, the Southwest with the Dublin area, or the North (RCD, Portrush, etc.) with Dublin. The problem with the Southwest is that Lahinch and Ballybunion are the only sure-fire winners. Waterville gets mixed reviews; I've heard good things about Dooks; the courses in Tralee and Dingle are only so-so, from what I've heard. And driving takes a long time in the SW.
I have a hard time thinking of going to Ireland without seeing Dublin. It's a world-class city. And, you have Portmarnock, Baltray, and the Island right there, with RCD not too far away. So, maybe fly into Shannon, play Lahinch and Ballybunion, go to Dublin, play your picks there, and fly out of Dublin.