John - you're right. The Lake Erie and Lake Ontario lakeshores offer some dramatic topography. Other than the short summers, it makes so much sense. It'd be a 1 day drive from Portland, ME to Richmond, VA. From Detroit, MI to Pittsburgh, PA.
And for a dark horse, pick the shoreline of one of the Finger Lakes, the best undiscovered vacation region in the NE.
I'd like to keep it in the USA, but the Ontairo side has some great locations too.